A: A healthy artery has a smooth, even surface. When too much cholesterol
builds up in the wall of your arteries, thick deposits called plaque form.
Plaque buildup narrows the width of an artery. When this happens, your heart must
work harder to force blood through it. Plaque can also break off and form clots.
When this happens in a major artery supplying the heart or brain, the blood and
oxygen flow can be significantly decreased. The result can be a heart attack or
stroke.